The peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion commonly caused by local irritation. This report describes\na 46-year-old Caucasian male who presented with a PGCG associated with a dental implant. The dental implant was originally\nplaced in August 2012. Ten months later, the patient presented with a well-circumscribed lesion associated with and covering the\nimplant, at which time the lesion was excised. Four months later, due to recurrence of the lesion, a deeper and wider excisional\nbiopsy with curettage of the adjacent bone was performed. No evidence of recurrence has been reported after 12 months of followup.\nImmunohistochemistry, using the antibody CD68, was performed to investigate the origin of the multinucleated giant cells,\nwith their immunophenotype being similar to those of other giant cell lesions, including central giant cell granuloma, foreign-body\nreactions, and granulomatous reactions to infectious agents.
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